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KMID : 1134819990280040958
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Journal of the Korean Society of Food Science and Nutrition
1999 Volume.28 No. 4 p.958 ~ p.962
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Measurement of Inhibitory Activities on 3 - Hydroxy - 3 - Methylglutaryl CoA Reductase and Acyl - CoA : Cholesterol Acyltransferase by Various Plant Extracts in vitro
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Lee Hee-Ja
Choi Myung-Sook
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Abstract
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Hydroxy-methylglutaryl CoA(HMG-CoA) reductase and acyl-CoA: cholesterol acyltransferase(ACAT) are two important enzymes that are associated with regulation of cholesterol metabolism. The inhibitors of HMG-CoA reductase and ACAT are very effective in lowering serum cholesterol in most animal species. In present study, various plant extracts with hot water were used to examine the inhibitory activities against HMG-CoA reductase and ACAT that are involved in cholesterol biosynthesis and cholesterol esterification in tissues, respectively. The extracts of Fagophyrum rotundatum, Rosa multiflora, Rosa rugosa and Alisma orientalis exhibited significant inhibitory activities against the ACAT, 29%, 24%, 19%, and 18%, respectively. However the extracts of Typha augustifolia, Polygonum cuspidatum, Crataegus pinnatifida, Polygonum multiflorum inhibited the HMG-CoA reductase activity by 53%, 42%, 37%, and 33% respectively. Results suggest that these plant extracts might play important roles in the regulation of the cholesterol metabolism in vivo.
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KEYWORD
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hydroxy-methylglutaryl CoA reductase, acyl-CoA, cholesterol acyltransferase, inhibitory activity, plant extracts
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